焦正
发表时间:2012-07-11 阅读次数:3895次

         

博士,主任药师,博士生导师,复旦大学附属华山医院药剂科副主任。 毕业于复旦大学药学院,曾两次赴美研修临床前药理和临床药理。主要研究方向为应用现代色谱学、药物基因组学和定量药理学技术,进行治疗药物监测和个体化给药。

 已完成国家自然科学基金项目1项,正主持1项,并参与国家教育部重点学科和国家科技部创新药物的临床研究平台项目的建设,承担国际青少年糖尿病基金会(JDRF)、国家和省部级课题十余项。

以第一或通讯作者身份表在Clin PK、BJCP、EJCP、等SCI杂志上发表研究论文逾20篇、国内权威或核心期刊论文30余篇,获国家发明专利10项,曾获得上海市优秀发明选拔赛金奖、银奖;上海市药学科技奖三等奖、上海市优秀成果奖等奖项。

现为中国药理学会定量药理、治疗药物监测专委会委员,美国临床药理学会(ACCP)会员,药学学报、中国临床药理学与治疗学杂志编委。

 曾被授予 “中国药理学会优秀青年药理学工作者”、 “复旦十大医务青年”、“药学学报优秀审稿人”、 “华山优秀教师”等荣誉称号。

 

代表性论文:

1.  Zhao Chen-yan, Jiao Zheng*, Mao Jun-jun, Qiu Xiao-yan. External Evaluation of Published Population Pharmacokinetic Models of Tacrolimus in Adult Renal Transplant Recipients. Br J Clin Pharmacol. 2016,81(5):891-907.

2.        Lin WW, Wu W, Jiao Z*, Lin RF, Jiang CZ, Huang PF, Liu YW, Wang CL*. Population pharmacokinetics of vancomycin in adult Chinese patients with post-craniotomy meningitis and its application in individualised dosage regimens. Eur J Clin Pharmacol. 2016; 72(1):29-37.

3.        Li Junfeng, Zhang Zhaoyun, Liu Xiaoxia, Wang Yi, Mao Fei, Mao Junjun, Lu Xiaolan, Jiang Dongdong, Wan Yun, Lv Jia-Ying, Cao Guoying, Zhang Jing, Zhao Naiqing, Atkinson Mark, Greiner Dale L., Prud’homme Gerald J., Jiao Zheng*, Li Yiming* and Wang Qinghua*. Study of GABA in healthy volunteers: pharmacokinetics and pharmacodynamics. Frontiers in Pharmacology. 2015, Vol(6), Article 260

4.        Yan Ming-Ming, Shen Chun-Ying, Zhang Liang, Ying Yin-Qing, Sun Pei-Nan, Jiao Zheng *. Vincristine drug safety administration survey: results from hospitals in Shanghai, China. Eur J Hosp Pharm. doi:10.1136/ejhpharm-2014-000567. 2015 22(5) 255-59. (IF=0.471) Print ISSN 2047-9956;Online ISSN 2047-9964       

5. Ding Jun-jie, Wang Yi, Lin Wei-wei, Wang Chang-lian, Zhao Li-mei, Li Xin-gang, Zhao Zhi-gang, Miao Li-yan, Jiao Zheng*. A Population Pharmacokinetic Model of Valproic Acid in Pediatric Patients with Epilepsy: A Non-Linear Pharmacokinetic Model Based on Protein-Binding Saturation. Clin Pharmacokinet. 2015, 54(3): 305-317. (IF=5.486) ISSN: 0312-5963 (Print) 1179-1926 (Online)

6.        Ling Jing, Shi Jun, Jiang Qiudi, Jiao Zheng*. Population pharmacokinetics of mycophenolic acid and its main glucuronide metabolite: a comparison between healthy Chinese and Caucasian subjects receiving mycophenolate mofetil. Eur J Clin Pharmacol. 2015, 71(1):95-106. (IF=2.697) Print ISSN 0031-6970;Online ISSN 1432-1041

7.        Lin Wei-Wei#, Jiao Zheng#, Wang Chang-Lian*, Wang Hua-Yan, Ma Chun-Lai, Huang Pin-Fang, Guo Xian-Zhong, Liu Yi-Wei. Population pharmacokinetics of valproic acid in adult Chinese epilepsy patients and ijts application in an individualised dosage regimen. Ther Drug Monit. 2015 37(1) 76-83. (IF=1.926) (并列第一)

8.    Zheng Yin, Xu Zhong-ye, Zhu Qiu-yu, Liu Jun-feng, Qian Jing, You Huai-zhou, Gu Yong, Hao Chuan-ming, Jiao Zheng*, Ding Feng*. Citrate Pharmacokinetics in critically ill patients with acute kidney injury. Plos One. 2013 8(6) e65992. (IF=3.534) eISSN 1932-6203

9.    Ding Jun-jie, Zhang Yun-jian, Jiao Zheng*, Wang Yi*. The effect of poor compliance on the pharmacokinetics of carbamazepine and its epoxide metabolite using Monte Carlo simulation. Acta Pharmacology Sinica, 2012, 33(11): 1431-40. (IF=2.496)

10.    Geng Fang, Jiao Zheng*, Dao Yi-jun, Qiu Xiao-yan, Ding Jun-jie, Shi Xiao-jin, Li Zhong-dong, Zhong Ming-kang. The Association of the UGT1A8, SLCO1B3 and ABCC2/ ABCG2 Genetic Polymorphisms with the Pharmacokinetics of Mycophenolic Acid and its Phenolic Glucuronide Metabolite in Chinese Individuals. Clin Chim Acta, 2012; 413(7-8): 683-90. (IF=2.764) ISSN: 0009-8981 

11.    Shi Xiao-jin, Geng Fang, Jiao Zheng*, Cui Xue-yan, Qiu Xiao-yan and Zhong Ming-kang. Association of ABCB1, CYP3A4*18B and CYP3A5*3 genotype with the pharmacokinetics of tacrolimus in healthy Chinese subjects: a population pharmacokinetic analysis. J Clin Pharm Ther. 2011; 36(5): 614-24. (IF=1.533) online ISSN: 1365-2710

12.    Qin Wei-wei, Jiao Zheng*, Zhong Ming-kang, Shi Xiao-jin, Zhang Jun, Li Zhong-dong, Cui Xue-yan. Simultaneous determination of procaine, lidocaine, ropivacaine, tetracaine and bupivacaine in human plasma by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878(15-16): 1185-9. (IF=2.694)

13.    Jiao Zheng, Shi Xiao-jin, Li Zhong-dong, Zhong Ming-kang. Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients. Br J Clin Pharmacol, 2009, 68(1):47-60. (IF=3.688)

14.    Qiu Xiao-yan, Jiao Zheng*, Zhang Ming, Zhong Long-jin, Liang Hui-qi, Ma Chun-lai, Zhang Liang, Zhong Ming-kang. Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients. Eur J Clin Pharmacol. 2008, 64(11):1069-84. (IF=2.697)

15.    Jiao Zheng, Ding Jun-jie, Shen Jie, Liang Hui-qi, Zhong Long-jin, Wang Yi, Zhong Ming-kang and Lu Wei-yue. Population pharmacokinetic modeling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9, Br J Clin Pharmacol, 2008,65(6):893-907. (IF=3.688)

16.    Dao Yi-jun, Jiao Zheng*, Zhong Ming-kang. Simultaneous determination of aciclovir, ganciclovir and penciclovir in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 2008, 867(2):270-6. (IF=2.694)

17.    Ma Chun-Lai, Jiao Zheng*, Yang Jie,Shi Xiao-Jin. Isocratic Reversed-Phase HPLC for Simultaneous Separation and Determination of Seven Antiepileptic Drugs and Two of their Active Metabolites in Human Plasma. Chromatographia. 2007, 65(5/6):267-275. (IF=1.37)

18.    Jiao Zheng, Zhong Jiao-yong, Zhang Ming, Shi Xiao-jin, Yu Yun-qiu, Lu Wei-yue. Total and free mycophenolic acid and its 7-O-glucuronide metabolite in Chinese adult renal transplant patients: pharmacokinetics and application of limited sampling strategies. Eur J Clin Pharmacol. 2007; 63(1):27-37. (IF=2.697)

19.    Jiao Zheng, Zhong Yan, Shen Jie, Yu Yun-qiu. Simple High-Performance Liquid Chromatographic Assay, with Post-Column Derivatization, for Simultaneous Determination of Mycophenolic Acid and its Glucuronide Metabolite in Human Plasma and Urine. Chromatographia. 2005, 62(7/8):363-371 (IF=1.37)

20.    Shen Jie, Jiao Zheng*, Li Zhong-dong, Shi Xiao-jin, Zhong Ming-kang. HPLC determination of telmisartan in human plasma and its application to pharmacokinetics study. Pharmazie. 2005, 60(6): 418-420

21.    Shen Jie, Jiao Zheng*, Yu Yun-qiu, Zhang Ming, Zhong Ming-kang. Quantification of total and free mycophenolic acid in human plasma by liquid chromatography with fluorescence detection J Chromatogr B Analyt Technol Biomed Life Sci, 2005, 817(2): 207-213. (IF=2.694)

22.    Jiao Zheng, Shi Xiao-jin, Zhao Zhi-gang, Zhong Ming-kang. Population Pharmacokinetic Modeling of Steady State Clearance of Carbamazepine and Its Epoxide Metabolite from Sparse Routine Clinical Data. J Clin Pharm Ther. 2004, 29(3): 247-256 (IF=1.533)

23.    Jiao Zheng, Zhong Ming-kang, Shi Xiao-jin, Zhang Jing-hua. Population pharmacokinetics of carbamazepine in Chinese Epilepsy Patients Ther Drug Monit, 2003, 25(3): 279-286 (IF=1.926)

24.    Ling Jing, Qian Li-xuan, Ding Jun-jie, Jiao Zheng. Effects of multiple-trough sampling design and algorithm on the estimation of population and individual pharmacokinetic parameters. Yao Xue Xue Bao. 2014, 49(5): 686−94. Chinese.

凌静,钱李轩,丁俊杰,焦正*. 谷浓度采样设计和算法对群体和个体药动学参数估算的影响. 药学学报. 2014, 49(5): 686−94. (封面论文) ISSN 0513-4870

25.    Ding Jun-jie, Jiao Zheng*, Wang Yi*. [Estimation of individual pharmacokinetic parameters using maximum a posteriori Bayesian method with D-optimal sampling strategy]. Yao Xue Xue Bao. 2011; 46(12): 1493-1500. Chinese.

丁俊杰,焦正*,王艺*. 基于D最优设计的最大后验贝叶斯法估算个体药动学参数. 药学学报,2011,46(12): 1493-1500.

26.    Ding Jun-jie, Jiao Zheng*, Yu Yun-qiu, Shi Xiao-jin. [Development and identifiability analysis of parent-metabolite pharmacokinetic model for risperidone and its main active metabolite 9-hydroxyrisperidone]. Yao Xue Xue Bao. 2007 Jun; 42(6):631-8. Chinese. PMID: 17702401 [PubMed - indexed for MEDLINE]

丁俊杰,焦正*,郁韵秋,施孝金. 利培酮和其主要活性代谢产物9羟基利培酮代谢动力学模型的建立和鉴别. 药学学报. 2007; 42(6):631-8.

27.    Ding Jun-jie, Jiao Zheng*, Li Zhong-dong, Shi Xiao-jin. [Bioequivalence assessment of pioglitazone hydrochloride oral preparation by limited sampling strategy]. Yao Xue Xue Bao. 2006; 41(9): 893-8. Chinese. PMID:17111840 [PubMed - indexed for MEDLINE]

丁俊杰,焦正*,李中东,施孝金. 有限采样法估算口服吡格列酮的生物等效性. 药学学报. 2006; 41(9): 893-8.

28.    Jiao Zheng, Shen Jie, Zhong Long-jin, Yu Yun-qiu, Zhong Ming-kang. [Pharmacokinetic model for the enterohepatic circulation of mycophenolic acid]. Yao Xue Xue Bao. 2006 Mar; 41(3): 272-6. Chinese. PMID:16759002 [PubMed - indexed for MEDLINE]

焦正,沈杰,仲珑瑾,郁韵秋,钟明康. 麦考酚酸肠肝循环药动学模型的建立. 药学学报. 2006,41(3): 272—276.

29.    Jiao Zheng, Liang Hui-qi, Ding Jun-jie, Li Zhong-dong, Shi Xiao-jin, Zhong Ming-kang. [Effect of MDR1 polymorphic expression on oral disposition of cyclosporine A]. Yao Xue Xue Bao. 2004 Dec; 39(12): 971-4. Chinese. PMID:15813023 [PubMed - indexed for MEDLINE]

 30. 焦正,梁惠琪,丁俊杰,李中东,施孝金,钟明康. MDR1基因多态性对口服环孢素A药动学的影响 药学学报,2004,39(12):971-974

 

 

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